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Direct and indirect induction of IL 12R2 by cAMPAs the above results suggest the involvement of IFN and IL 2 in a part of cAMP induced Il12rb2 expression by TCR activated T cells, we next evaluated how and how much IFN and IL 2 contribute to cAMP induced Il12rb2 expression by stimulating T cells with or without [url=http://www.piktor.fr/hollister/]hollister[/url] TCR activation, with or without IFN signalling, and in the presence or absence of cAMP for 12h. In WT T cells, while db cAMP, IFN or TCR activation alone induced Il12rb2 expression at a similar level, cAMP synergistically induced Il12rb2 expression in the presence of IFN or TCR or both (Fig. 2a).
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